Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides

Table 3 Summary of highest CDP titres ever reported for bacterial and fungal expression hosts

CDP	Native producer	Heterologous producer
Enniatin B	5 g/L (enniatin B and other derivatives) F. oxysporum Shake flask cultivation [70]	1.1 mg/L B. subtilis Shake flask cultivation [23]	950 mg/L A. niger Shake flask cultivation [27]
Enniatin B		1.1 mg/L B. subtilis Shake flask cultivation [23]	4.5 g/L A. niger Bioreactor cultivation [27]
Beauvericin	420 mg/L F. oxysporum Shake flask cultivation [20]	74.1 ± 0.3 mg/L S. cerevisiae Shake flask cultivation [24]	628.4 ± 211.1 mg/L A. niger Shake flask cultivation [This study]
Beauvericin	22.3 ± 1.5 mg/L B. bassiana Shake flask cultivation [24]	8 mg/L E. coli Shake flask cultivation [22]	113.4 mg/L A. niger Bioreactor cultivation [This study]
Bassianolide	18.2 ± 0.6 mg/L B. bassiana In shake flask cultivation [24]	26.7 ± 2.8 mg/L S. cerevisiae Shake flask cultivation [24]	378.77 ± 59.74 mg/L A. niger Shake flask cultivation [This study]
Bassianolide			322.12 mg/L A. niger Bioreactor cultivation [This study]

For simplicity, respective strain names, genetic modifications and details on cultivation conditions (medium composition, cultivation time, feeding conditions, etc.) are not indicated for the different cell factories. This data can be extracted from the references given

ISSN: 2054-3085